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ea0035p731 | Neuroendocrinology | ECE2014

Influence of the exon 3 deletion of GH receptor and IGF1 level at diagnosis on the efficacy and safety of treatment with somatotropin in adults with GH deficiency

Andujar-Plata Paula , Fernandez-Rodriguez Eva , Quinteiro Celsa , Casanueva Felipe , Bernabeu Ignacio

Introduction: Human recombinant growth hormone (hrGH) treatment in adult patients with GH deficiency (GHD) has an important interindividual variability and several factors can influence it. The aims of the study were: i)- to analyze the genotype of GHR regarding exon 3 deletion (d3-GHR) in a serie of adult patients with GHD; ii)- to assess the effect of d3-GHR on initial IGF1 levels; iii)- to evaluate if d3-GHR and/or initial IGF1 levels were associated with adverse effects an...

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Endocrine Abstracts

Influence of the exon 3 deletion of GH receptor and IGF1 level at diagnosis on the efficacy and safety of treatment with somatotropin in adults with GH deficiency

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